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Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis

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Altered cellular metabolism is a hallmark of tumorigenesis. Described first in 1924 by Otto Warburg, a cancer cell undergoes complete metabolic reprogramming to attain nutrient self-sufficiency for proliferation and survival. Interplay between diverse signalling cascades confers this metabolic advantage. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor.





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Keywords: Akt; Fibroblast growth factor receptor (FGFR); Hexokinase II; Myc; Pyruvate kinase; SGLT2 expression; Warburg effect; aerobic glycolysis; glutaminolysis; hypoxic tumor cells; isozymes; mTOR; mitochondrial outer membrane; tumor cell populations

Document Type: Research Article

Publication date: March 1, 2011

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