How to Control Accessibility to Biosensor Probes?
A strategy to design biolayers where accessibility to the probes is controlled was presented in this study. The access volume of probe in the biolayer was optimized by grafting on the transducer surface a probe bonded to a target biomolecule. This strategy, illustrated in this study
in the case of a quartz crystal microbalance DNA biosensor, permits to match higher hybridization efficiency than known design schemes. The biolayer is well adapted for the detection of large DNA targets in which hybridization efficiency may decrease drastically due to steric hindrance in
the biolayer.
Keywords: DNA BIOSENSOR; QCM; SELF ASSEMBLED MONOLAYER
Document Type: Research Article
Publication date: 01 October 2009
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