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Biosynthesis and Characterization of Zinc Oxide Nanoparticles for the Systemic Treatment of Patients with Lymphoma in Nursing Care

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Zinc oxide (ZnO) nanoparticles recently are of significant consideration because of their applications as nontoxic metal oxides. This study is mainly intended to improve a simple, efficient, and environment-friendly method for preparation of ZnO nanoparticles. This process has been developed based on plant-intervened synthesis by making use of microwave Saturejahortensis aqueous extract. We have further characterized the obtained Zinc oxide nanoparticles by using different techniques. Additionally, their cytotoxic potential was inspected via MTT assay against both B lymphoma, A20 and T lymphoma, EL4 cells lines. The zinc oxide nanoparticle exposed cells for about 24 h showed diminished cell viability in the tested cell lines where EL4 cells has been reduced to 75% of control after 24 h, whereas A20 cells were lowered to 68% of control. ZnO-NPs have proficiently hindered EL4 cell DNA synthesis at 100 μg concentration whereas completely blocked the DNA proliferation at about 50 g concentration. However, A20 cells besides presented similar propensity, thus exploring the ZnO-NPs potential to treat lymphomas.
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Keywords: CYTOTOXICITY; DNA PROLIFERATION; MTT ASSAY; ZINC OXIDE NANOPARTICLES

Document Type: Research Article

Publication date: January 1, 2020

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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