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Synthesis of Baicalein Modified Cerium Oxide Nanoparticles for Inhibitory Activation of NF-κB and Mitogen-Activated Protein Kinase Signals in Rotenone-Induced Parkinsonian Rats

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Baicalein is one of the chief flavones extracted from Scutellariabaicalensis georgi which was earlier reported for its neuroprotective efficacy against Parkinson's disease (PD). In the present study, a simple and efficient synthetic procedure for the preparation of CeO2NPs using Ce(NO3)3 as a primary precursor and baicalein as a stabilizing agent was proposed. Further, the neuroprotective response of baicalein stabilized CeO2 NPs against rotenone-stimulated parkinsonian diseased mice has been explored both in-vitro and in-vivo. From the experimental findings, it was also evident that baicalein exposure has enhanced the motor impairments, and hindered the pro-inflammatory cytokine release and blocked the NF-κB along with MAPK signaling pathway in rotenone-stimulated PD rat models.
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Keywords: BAICALEIN; CERIUM OXIDE NPS; MAPK; NF-κB; PARKINSON'S DISEASE

Document Type: Research Article

Publication date: January 1, 2020

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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