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Recent Advances in Colorectal Cancer-Specific Nucleic Acid Aptamers for Diagnostic and Therapeutic Applications

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Colorectal cancer is the third leading cause of cancer death, and its incidence is continuing to increase rapidly in developing countries. Thus, it is clinically important to achieve an early diagnosis and early treatment for colorectal cancer. Aptamers, also known as chemical antibodies, are short, single-stranded oligonucleotide ligands selected by systematic evolution of ligands by exponential enrichment (SELEX). Because of their excellent chemical properties, such as easy synthesis, controllable modifications, long-term stability, low immunogenicity, and fast tissue penetration, aptamers have good application prospects in cancer diagnosis as well as therapy, and some are in clinical trials. In this review, we discuss aptamers that have been developed for colorectal cancer, and then briefly highlight applications of aptamers in colorectal cancer diagnosis and therapy.
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Document Type: Review Article

Publication date: January 1, 2020

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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