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Indocyanine Green Accurately Track the Phototherapy Based on W18O49@PLGA Nanostructure In Vivo for Visual Treat

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With the progress and development of technology, compared with traditional chemotherapy and other surgical methods, photothermal therapy has been paid more attention and attempted in the treatment of many diseases due to its non-invasive and minimal secondary effect. Tungsten oxide (W18O49, WO), an overly coherent oxide nanoparticle, is an attractive option for high-quality PTT effects. Poly(D,L-lactic-co-glycolic acid) has good biocompatibility and biodegradability, and is a supporting component widely used in pharmaceutical emissions. However, the commonly used hydrothermal method is difficult to limit the morphology of WO. In this paper, Indocyanine green and WO coloaded PLGA ((WO+ICG)@PLGA) were preliminarily designed and prepared. The photothermal mass during ICG imaging can be effectively improved by (WO+ICG)@PLGA nanoparticles, to guide PTT. The results of in vivo experiments showed that nanoparticles had good effects on imaging and photothermal therapy for B16 tumor cells in vivo. The study indicated that (WO+ICG)@PLGA nanoparticles are an excellent platform for the diagnosis and photothermal therapy of inflammation-related diseases.
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Keywords: INDOCYANINE GREEN; NEAR-INFRARED LIGHT; PHOTOTHERMAL THERAPY; PLGA; TUNGSTEN OXIDE (W18O49, WO)

Document Type: Research Article

Publication date: October 1, 2019

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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