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Silver Modified Tricalcium Phosphate for Biomedical Application: Structural Investigation and Study of Antimicrobial with Histopathological Activity

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Addition of silver oxide (Ag2O = 1.0 mol%) to 40P2O5–20Na2O–10Ca(OH)2–20CaCl2–9.0ZnO in mol% bioglasses (BGAg) have been prepared by melt-quench technique. The structural of present glasses investigated by using Raman spectra, scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray diffraction XRD. In the present paper, we tested antimicrobial activity, anti-proliferative/cytotoxicity against normal and activated splenic cells in vitro, in vivo immunologic and hypersensitivity responses on the present glasses. Here the results showed that BGAg had antimicrobial activities against Gram negative and positive bacteria as well as fungi. Also, the bioglasses (BGAg) has no cytotoxic or proliferative effects on activated splenic cells while showed proliferation stimulation potential on normal splenic cells. The nanoparticle of bioglasses (BGAg) showed growth inhibition/cytotoxic effects on normal splenic cells. In vivo test demonstrated that BGAg is an inert material which did not stimulate the immune system or caused local reactions which did not cause any acute cytotoxicity or lysis to RBCs. From the histopathological study we can consider that bioglasses (BGAg) as a safe and ideal material for implantation inside the body of living organisms.
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Keywords: ANTIBACTERIAL; BIOGLASSES; HYPERSENSITIVITY; SEM; SILVER OXIDE; TEM; XRD

Document Type: Research Article

Publication date: October 1, 2019

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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