Silver Modified Tricalcium Phosphate for Biomedical Application: Structural Investigation and Study of Antimicrobial with Histopathological Activity
Addition of silver oxide (Ag2O = 1.0 mol%) to 40P2O5–20Na2O–10Ca(OH)2–20CaCl2–9.0ZnO in mol% bioglasses (BGAg) have been prepared by melt-quench technique. The structural of present glasses investigated by using Raman spectra, scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray diffraction XRD. In the present paper, we tested antimicrobial activity, anti-proliferative/cytotoxicity against normal and activated splenic cells in vitro, in vivo immunologic and hypersensitivity responses on the present glasses. Here the results showed that BGAg had antimicrobial activities against Gram negative and positive bacteria as well as fungi. Also, the bioglasses (BGAg) has no cytotoxic or proliferative effects on activated splenic cells while showed proliferation stimulation potential on normal splenic cells. The nanoparticle of bioglasses (BGAg) showed growth inhibition/cytotoxic effects on normal splenic cells. In vivo test demonstrated that BGAg is an inert material which did not stimulate the immune system or caused local reactions which did not cause any acute cytotoxicity or lysis to RBCs. From the histopathological study we can consider that bioglasses (BGAg) as a safe and ideal material for implantation inside the body of living organisms.
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Document Type: Research Article
Publication date: October 1, 2019
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