Preparation of pH-Responsive Hydroxyapatite-Encapsulated Magnetic Fe3O4 Composite Materials with Sandwich Construction for Drug Delivery of Doxorubicin
Novel dandelion-flower-like composite materials containing a hydroxyapatite (HAP) micro-scaffold, SiO2-coated Fe3O4 magnetite nanoparticles and a thin HAP shell have been successfully synthesized and evaluated as micro-carriers of doxorubicin (DOX) for cancer therapy. The scaffold, a peony-flower-like HAP crystalline, displays hierarchical structure and large surface-area-to-volume ratio to increase the drug payload. The outer HAP layer exhibits to improve the serum stability of drug delivery system. Due to the design of sandwich construction, HAP plays a pivotal dual role not only in acting as a drug depot, but also in rendering the drug release rate with a highly pH-dependent controlled manner. DOX release from HAP/Fe3O4@SiO2/DOX/HAP composite was efficiently inhibited at physiological pH (pH 7.4), while was facilitated at an endosomal pH (pH 4.5). The anti-cancer efficacy toward HeLa cells was also evaluated, exhibiting its potential as candidate for practical application in drug-delivery for therapeutic approaches.
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Document Type: Research Article
Publication date: October 1, 2019
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