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Preparation of pH-Responsive Hydroxyapatite-Encapsulated Magnetic Fe3O4 Composite Materials with Sandwich Construction for Drug Delivery of Doxorubicin

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Novel dandelion-flower-like composite materials containing a hydroxyapatite (HAP) micro-scaffold, SiO2-coated Fe3O4 magnetite nanoparticles and a thin HAP shell have been successfully synthesized and evaluated as micro-carriers of doxorubicin (DOX) for cancer therapy. The scaffold, a peony-flower-like HAP crystalline, displays hierarchical structure and large surface-area-to-volume ratio to increase the drug payload. The outer HAP layer exhibits to improve the serum stability of drug delivery system. Due to the design of sandwich construction, HAP plays a pivotal dual role not only in acting as a drug depot, but also in rendering the drug release rate with a highly pH-dependent controlled manner. DOX release from HAP/Fe3O4@SiO2/DOX/HAP composite was efficiently inhibited at physiological pH (pH 7.4), while was facilitated at an endosomal pH (pH 4.5). The anti-cancer efficacy toward HeLa cells was also evaluated, exhibiting its potential as candidate for practical application in drug-delivery for therapeutic approaches.
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Document Type: Research Article

Publication date: October 1, 2019

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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