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Fabrication of Collagen/HAP Electrospun Scaffolds with Perfect HAP Nanorods Along Nanofiber Orientation

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The purpose of this study is the preparation and characterization of collagen/hydroxyapatite (HAP) fibrous scaffolds with perfect HAP nanorods along nanofiber orientation by combining electrospinning and a chemical precipitation method. Two steps were employed in the composites preparation. First, long rod-like HAP were synthesized through a chemical pathway from Ca(NO3)2 · 4H2O, (NH4)2HPO4, and CO(NH2)2, the pH and the aging time played a key role of the phase of HAP and the particle size as well as distribution. The subsequent electrospinning was performed to fabricate the bone-like collagen/HAP fibrous scaffolds by aligning HAP nanorods within the collagen nanofibers. Our results have proved that oriented collagen/HAP fibrous scaffolds with HAP nanorods highly orientation can be obtained, starting from collagen, cheap Ca(NO3)2 · 4H2O and (NH4)2HPO4, through a very simple and accessible method. The resulted composite materials were characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and the formation mechanism of the layout and orientation of HAP nanorods within the collagen/HAP electrospun scaffolds has been proposed for the first time. HAP nanorods with highly oriented along the long axes of the collagen matrix significantly enhanced the mechanical properties of the corresponding scaffold. This combination of fibrous collagen and HAP nanorods with the wonderful structure mimics the nanoscale features of the extra cellular matrix could be promising for application as scaffolds in medical fields.
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Keywords: COLLAGEN; ELECTROSPINNING; FIBROUS SCAFFOLDS; HYDROXYAPATITE; ORIENTATION

Document Type: Research Article

Publication date: July 1, 2018

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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