A Comparison of the Toxic Effects of Fluorescent Silicon Nanoparticles in Males and Females of the Silkworm Bombyx mori
The reproductive system is known to be more sensitive to exogenous materials than other organ systems. However, the toxicity of silicon nanoparticles (SiNPs) on components of the reproductive system in vivo has not been investigated. We aimed to investigate the toxic effects of SiNPs on the gonads of an invertebrate model organism, Bombyx mori. Dorsal vascular injection of a maximal dose of 3.9 μg of SiNPs per larva allows SiNPs to rapidly enter the gonads, inducing the generation of reactive oxygen species in the outer membranes of the testes and ovaries. It also induces early germ cell death or developmental abnormality by activating the germ cell apoptosis pathway, resulting in reductions in oviposition and spermatogenesis and subsequently leading to decreased sperm quality and fertilization rates in later generations of males. The reproductive toxicity of SiNPs was associated with a certain male sensitivity and had potentially adverse effects on oviposition behavior in mating females.
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Document Type: Research Article
Publication date: March 1, 2018
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