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A Comparison of the Toxic Effects of Fluorescent Silicon Nanoparticles in Males and Females of the Silkworm Bombyx mori

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The reproductive system is known to be more sensitive to exogenous materials than other organ systems. However, the toxicity of silicon nanoparticles (SiNPs) on components of the reproductive system in vivo has not been investigated. We aimed to investigate the toxic effects of SiNPs on the gonads of an invertebrate model organism, Bombyx mori. Dorsal vascular injection of a maximal dose of 3.9 μg of SiNPs per larva allows SiNPs to rapidly enter the gonads, inducing the generation of reactive oxygen species in the outer membranes of the testes and ovaries. It also induces early germ cell death or developmental abnormality by activating the germ cell apoptosis pathway, resulting in reductions in oviposition and spermatogenesis and subsequently leading to decreased sperm quality and fertilization rates in later generations of males. The reproductive toxicity of SiNPs was associated with a certain male sensitivity and had potentially adverse effects on oviposition behavior in mating females.
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Keywords: IN VIVO/IN VITRO TEST; REPRODUCTIVE TOXICITY; SEXUAL DIFFERENCE; SILICON NANOPARTICLES

Document Type: Research Article

Publication date: March 1, 2018

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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