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Preparation and Drug-Delivery Properties of Hybrid Materials MOFs/Graphite Oxide

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Hybrids MIL-53/GO and MIL-101/GO were synthesized and were applied for the drug delivery. The adsorption for IBU (ibuprofen) on MOFs/GO and MOFs were compared and it was found that the addition of GO enhanced IBU loading and stability. The drug release experiments of IBU loaded MOFs and MOFs/GO were conducted, and it was found that drug release of MOFs/GO was slower, which can be explained for the hydrogen bonding between GO and IBU. It also exposed that the IBU loading of MIL-101 (Cr) and MIL-101/GO were both larger than that of MIL-53 (Fe) and MIL-53/GO, meaning that metal ions had an effect on the pore size which will effect on the selectivity on the adsorption for different drug molecules. Drug carrier can be designed according to different size drug molecules through the formation of MOFs/GO with optimal metal ions.
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Keywords: DRUG DELIVERLY; DRUG LOADING; DURG RELEASE; IBUPROFEN; MOFS/GO

Document Type: Research Article

Publication date: August 1, 2016

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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