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Preparation and Characterization of Silver Nanoparticles Composited on Polyelectrolyte Film Coated Sericin Gel for Enhanced Antibacterial Application

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Sericin has shown a great potential as a biomaterial in biomedical application due to its good hydrophilicity, reactivity and biodegradability. To solve the adherence and growth of microorganisms on sericin gel, here we prepared a polyelectrolyte film with interactive arrangement of opposite charges poly(dimethyldiallylammonium chloride) (PDDA) and poly(acrylic acid) (PAA) coated on the surface of sericin gel via electrostatic interaction. AgNPs was then synthesized with the assistance of UV in situ on the polyelectrolyte film to endow the antibacterial activity of sericin gel. SEM revealed the polyelectrolyte film could effectively facilitate the high density growth of AgNPs as a 3-D matrix and the modification of polyelectrolyte and AgNPs did not alter the porous characteristics of sericin gel. XRD studies suggested AgNPs synthesized on the polyelectrolytes film coated sericin gel had good crystal structure. DSC analysis showed AgNPs could tightly bind with the polyelectrolytes film and sericin gel, and the binding may improve the melting temperature of AgNPs. Both bacterial inhibition zone and growth curve assay demonstrated the sericin gel coated with AgNPs-polyelectrolytes film had an excellent and long-lasting antibacterial activity. This novel sericin gel has shown great potentials in biomedical application such as wound healing.
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Keywords: ANTIBACTERIAL APPLICATION; POLYELECTROLYTE FILM; SERICIN GEL; SILVER NANOPARTICLES

Document Type: Research Article

Publication date: August 1, 2016

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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