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Effect of Titanium Dioxide Nanoparticles on Silkworm's Innate Immunity and Resistance to Bacillus bombyseptieus

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Titanium dioxide nanoparticles (TiO2 NPs) has been widely used in medicine and biology. Low dose TiO2 NPs can improve silkworm's resistance against virus disease, however, the effect of TiO2 NPs on silkworm innate immunity and bacterial disease has not been reported. In this study, we performed digital gene expression profile (DGE) analysis for silkworm midgut, which revealed that pretreatment with TiO2 NPs caused significant changes in 15 pathways (P<0.05), including tyrosine metabolism and melanogenesis. Results from ontology annotation and pathway analysis indicated that the differentially expressed genes mainly participated in immune response, defense response, energy metabolism, and apoptosis. Silkworms pretreated with TiO2 NPs increased survival rate of 13.30% when infection with Bacillus bombyseptieus (Bb), reduced not only the phenol oxidase cascade but also the activation levels of Toll and Imd induced by Bb. Moreover, TiO2 NPs also inhibited the silkworm apoptosis induced by Bb. The present study is the first one that clarifies the mechanism of TiO2 NPs' effect on silkworm's resistance against Bb, which is through the early activation of the innate immunity. The results presented here provide a new method for the application of TiO2 NPs in silkworm disease prevention.
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Keywords: BACILLUS BOMBYSEPTIEUS; BOMBYX MORI; INNATE IMMUNITY; TITANIUM DIOXIDE NANOPARTICLES

Document Type: Research Article

Publication date: August 1, 2016

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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