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A Biomemory Device Based on Electrically Controlled Hemin/G-Quadruplex Complex

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Various DNA-based circuits that use material inputs and outputs do not properly connect nor co-operate with other electrically controlled systems on a chip. Thus, the development of a closed system operated by electrical signals for DNA-based biodevices is needed. Here, a novel label-free biomemory device was proposed to implement memory functions for “write,” “erase,” and “read.” The device was based on structural transformation of the hemin/G-quadruplex complex via electrical control without using materials. Two electrochemical systems in a single chamber, termed “controller” and “operator,” were constructed to achieve memory functions. Applied potentials of –0.054 and –0.339 V in the controller were used to operate the operator with “write” and “erase” functions, respectively. These potentials led to H+ and OH generation in the controller, which resulted in the formation and deformation of the hemin/G-quadruplex complex in the operator. In a cyclic voltammogram of the operator, two different current levels of reduction peaks for the “read” function were read as “1” and “0” with respect to the structural formation and deformation. The constructed device was a stable, durable, and reliable write-once-read-many-times (WORM) memory device. These features of the proposed biomemory device provide a feasible and promising method for applications in DNA-based biocomputing devices.
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Document Type: Research Article

Publication date: April 1, 2016

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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