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CaCO3 Rods as Chitosan-Polygalacturonic Acid Carriers for Bromopyruvic Acid Delivery

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The natural properties of chitosan (CHI), such as biocompatibility and biodegradability, have stimulated its use as drug delivery carrier in several applications, including layer-by-layer assembly and polymer self–assembly. In this work we have aimed at producing chitosan microtubes by using CaCO3 rods doped with poly allylamine hydrochloride (PAH) as templates. The shape of the CaCO3 particles could be controlled upon addition of PAH during synthesis. A CHI-PgA complex was formed upon electrostatic binding of polygalacturonic acid (PgA) to CHI, to produce capsules for bromopyruvic acid delivery. Morphological investigations of the size and shape of CaCO3 rods were performed by means of scanning and transmission electron microscopy techniques. Infrared spectroscopy was used to monitor the characteristic bands in PAH, CHI, PgA and CaCO3. Cellular uptake and cytotoxicity were investigated. Control of CaCO3 growth during synthesis towards elongated shapes by using PAH was confirmed. These results envisage the use of chitosan-polygalacturonic acid micro/nanotubes as efficient drug delivery system for encapsulation of bromopyruvic acid as blocker for glycolytic enzymes.
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Keywords: BROMOPYRUVIC ACID; CALCIUM CARBONATE; CHITOSAN-POLYGALACTURONIC ACID COMPLEX; DRUG DELIVERY; NANOCAPSULES; NANORODS

Document Type: Research Article

Publication date: March 1, 2016

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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