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Disulfide Cross-Linked Amphiphilic Copolymers Loading Doxorubicin for Controlled Drug Delivery

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An amphiphilic copolymer, PEG-b-PLA-b-(PAA-co-PNIPAM), was synthesized via atom transfer radical polymerization of tert-butyl acrylate and N-isopropyl acryamide using PEG-b-PLA-Br as a macroinitiator and CuBr/Me6 TREN as a catalytic system, followed by selectively hydrolyzing tert-butyl groups to carboxyl groups. Then, doxorubicin (DOX) was loaded to the hydrophobic core, and the PAA segments were cross-linked by cystamine to get disulfide cross-linked and DOX loaded micelles. The transmission electron microscopy images showed that the cross-linked DOX loaded micelles were spherical nanoparticles, with a mean diameter of 100 nm. The drug release behavior of the cross-linked DOX loaded micelles was redox responsive. The cumulative release amount of DOX was 33.1% with the presence of 10 mM of glutathione (GSH) at 37 °C, much higher than that without the presence of GSH, which was only 4.3%. Furthermore, the cumulative release amount of DOX was 50.9% at 25 °C, higher than that at 37 °C, indicating that the cross-linked DOX loaded micelles were also thermo-sensitive.
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Document Type: Research Article

Publication date: May 1, 2015

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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