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In SituPreparation of Size-Controlled Iron Oxide Nanocrystals Using Double-Hydrophilic Multiarm Hyperbranched Polymers as Nanoreactors and Their Magnetofection In Vitro

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In situ preparation of size-controlled magnetic iron oxide nanocrystals (NCs) within double-hydrophilic multiarm hyperbranched polymers and their application as magnetic nonviral gene vectors for magnetofection has been proposed. The double-hydrophilic multiarm hyperbranched polymers were conveniently constructed by grafting poly(ethylene glycol) methyl ether acrylate (PEGMEA) molecules to hyperbranched poly(ethylenimine)s (HPEI) with the help of Michael addition. HPEI conjugates with 7.5, 15.7 and 23 PEGMEA grafts (referred to as HPEI-PEGMEA7.5, HPEI-PEGMEA15.7 and HPEI-PEGMEA23, respectively) were synthesized. By introducing biocompatible PEGMEA molecules to HPEI, the cytotoxicity of the resulting HPEI-PEGMEA can be greatly decreased compared with HPEI. The HPEI-PEGMEA double-hydrophilic hyperbranched polymers were then used as nanoreactors and stabilizers to prepare size-controlled magnetic iron oxide nanocrystals. With the increase of PEGMEA arms, the size and magnetization of magnetic iron oxide NCs were improved, resulting in the enhancement of gene transfection efficiency. The resulting magnetic gene vectors had magnetic targeting, low cytotoxicity and their magnetofection efficiency could reach 4.5 fold of that for standard HPEI transfection.
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Keywords: DOUBLE-HYDROPHILIC MULTIARM HYPERBRANCHED POLYMERS; IRON OXIDE NANOCRYSTALS; MAGNETOFECTION; NANOCOMPOSITES

Document Type: Research Article

Publication date: February 1, 2015

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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