Anticancer Activities of Silver-Coated Maghemite
Silver-coated γ-Fe2O3 such as Ag/γ-Fe2O3 and, were synthesized and characterized for their anticancer activities. The Ag/γ-Fe2O3 nanoparticles sizes are ranges from 34 to 46 nm. The characteristics of these particles were determined via X-ray diffraction, field emission scanning electron microscopy, and Raman spectrometer. The nanocomposites were prepared by the in situ chemical reduction of silver ions in the presence of oleic acid. A magnetic phase, along with the molecules of polyethylene glycol, served as the spacer between the iron oxide and the silver nanoparticles. The results demonstrated that the Ag/γ-Fe2O3 nanoparticles were spherical. A cell viability assay revealed that the Ag/γ-Fe2O3 nanoparticles could inhibit the proliferation of cancer cells in a dose-dependent manner. In contrast, the magnetic nanoparticles showed a non-toxic activity against normal and cancer cells. More specifically, the 70% Ag-coated γ-Fe2O3 nanoparticles were 52.16% cytotoxic to the DU145 prostate cancer cells, 50% cytotoxic to the HeLa cervical cancer cells, 67% cytotoxic to the MCF-7 breast cancer cells, 57% cytotoxic to the U87 glioblastoma cancer cells, and 63.7% cytotoxic to the HS68 normal cells. Our results suggest that the Ag/γ-Fe2O3 nanocomposites could find applications as versatile anti-cancer agents.
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Document Type: Research Article
Publication date: November 1, 2014
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