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Anticancer Activities of Silver-Coated Maghemite

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Silver-coated γ-Fe2O3 such as Ag/γ-Fe2O3 and, were synthesized and characterized for their anticancer activities. The Ag/γ-Fe2O3 nanoparticles sizes are ranges from 34 to 46 nm. The characteristics of these particles were determined via X-ray diffraction, field emission scanning electron microscopy, and Raman spectrometer. The nanocomposites were prepared by the in situ chemical reduction of silver ions in the presence of oleic acid. A magnetic phase, along with the molecules of polyethylene glycol, served as the spacer between the iron oxide and the silver nanoparticles. The results demonstrated that the Ag/γ-Fe2O3 nanoparticles were spherical. A cell viability assay revealed that the Ag/γ-Fe2O3 nanoparticles could inhibit the proliferation of cancer cells in a dose-dependent manner. In contrast, the magnetic nanoparticles showed a non-toxic activity against normal and cancer cells. More specifically, the 70% Ag-coated γ-Fe2O3 nanoparticles were 52.16% cytotoxic to the DU145 prostate cancer cells, 50% cytotoxic to the HeLa cervical cancer cells, 67% cytotoxic to the MCF-7 breast cancer cells, 57% cytotoxic to the U87 glioblastoma cancer cells, and 63.7% cytotoxic to the HS68 normal cells. Our results suggest that the Ag/γ-Fe2O3 nanocomposites could find applications as versatile anti-cancer agents.
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Document Type: Research Article

Publication date: November 1, 2014

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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