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Antibacterial and Functional Properties Enhancement of Mesoporous Calcium-Silicate Nanoparticles by Coupling with Quaternary Ammonium Chloride

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Apical bone defect is one of the most common consequences of chronic apical periodontitis. The present study aimed to enhance the antibacterial and functional properties such as ions release, biocompatibility, cytotoxicity, and mineralization of the mesoporous calcium-silicate nanoparticles (MCSNs) by incorporation with quaternary ammonium compounds (QAC) using a mixing-coupling method. The results revealed that QAC molecules were successfully modified onto the MCSNs by the mixing-coupling method. These QAC modified MCSNs (M-QAC) nanoparticles have sub-globular structures (diameters 100 to 200 nm) and pores inside the nanoparticles (pore sizes 2 to 4 nm), with stable pH during 9 days (10 for MCSNs and 9.5 for M-QAC). The M-QAC nanoparticles exhibited significantly lower release of Ca2+ and SiO3 2– ions than MCSNs. Neither MCSNs nor M-QAC nanoparticles synthesized in this study showed any cytotoxic effect on MC3T3-E1 cells. The functionalized nanoparticles demonstrated significant inhibitory effects on bacterial attachment, without compromising the proliferation ability of MC3T3-E1 cells. Moreover, in simulated body fluids, massive mineralization and crystallization were observed on the surfaces of compacted nanoparticle tablets. In conclusion, the M-QAC nanoparticles synthesized in this study can be used as an effective filling material for infected apical bone lesions of human teeth.
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Document Type: Short Communication

Publication date: September 1, 2017

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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