A Note on the Biocompatibility of Zinc Oxide Nanoparticles in Male Albino Mice
The present study was conducted to account for the synthesis, characterization and biocompatibility of zinc oxide nanoparticles (ZnO NPs) in adult male albino mice. ZnO NPs were synthesized by the sol–gel auto-combustion method and then characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and tunneling electron microscopy (TEM). The XRD confirmed the formation of single phase ZnO. The average particle size ranged from 40 to 55 nm as detected by SEM and TEM. Ten week old male albino mice were divided into four experimental groups; A, B and C were orally treated with 50 (low dose), 300 (medium dose) and 600 mg/ml solvent/kg body weight (high dose) of ZnO NPs for four days. The complete blood count, serum biochemical parameters and histological changes in vital organs of mice were determined in all four experimental treatments. Results indicated significantly higher Bilirubin levels in mice exposed to medium (p = 0.01) and high doses (p = 0.002) of ZnO NPs as compared to control group. ALT concentrations were significantly lower (p = 0.05) while creatinine was significantly higher (p = 0.04) in mice exposed to low and high dose of NPs respectively. Histological analysis of liver and kidney in four treatments revealed a dose dependent effect of NPs on anatomy of studied vital organs. It was observed that oral treatment of 50 mg/ml solvent/kg body weight of ZnO NPs did not caused in any obvious health hazard in subjects. In contrast, the higher doses had reasoned toxicity in the subject animals. Based on our results, it is recommended that ZnO NPs should be used at less than 50 mg/ml solvent/kg body weight concentrations in commercial products.
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Document Type: Short Communication
Publication date: March 1, 2017
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- Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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