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Polylactide-Poly(ethylene glycol) Nanomicelles Encapsulating 20(S)-Hydroxycholesterol Enhance Osteogenic Differentiation and Mineralization of Bone Marrow Stromal Cell Line

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20(S)-Hydroxycholesterol (20S-OXY) is a specific oxysterol that has potent osteoinductive properties and an excellent candidate for fracture treatment and jaw surgery as a possible rhBMP2 alternative. However, it is a water-insoluble substance with hydrophobic property that limits its applications. 20S-OXY is difficult to load onto hydrophilic surface and can be released rapidly into the surrounding fluid environment. This not only results in short-lived stimulation of osteogenic differentiation but also leads to burst release, which is likely accompanied by tissue injury. Polylactide-poly(ethylene glycol) (mPEG-PLA) nanomicelles are a sustained-release dosage form that can solubilize insoluble drugs and reduce their toxic side effects. We prepared mPEG-PLA nanomicelles encapsulating 20S-OXY, with the aim of prolonging the duration of drug action and improving its hydrophobicity. The average diameter of the spherical micelles was approximately 58.94 nm. The in vitro release time for the 20S-OXY-loaded micelles was longer than that of free 20S-OXY, and the effects of 20S-OXY-loaded micelles acting on M2-10B4 cells (a mouse multipotent bone marrow stromal cell line) showed that the 20S-OXY-loaded mPEG-PLA micelles resulted in more effective osteogenic differentiation-related performance. In summary, the 20S-OXY-loaded mPEG-PLA micelles can be a potential drug delivery system for 20S-OXY in bone regeneration applications.
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Keywords: 20(S)-HYDROXYCHOLESTEROL; MICELLE; OSTEOGENIC DIFFERENTIATION; SUSTAINED RELEASE

Document Type: Short Communication

Publication date: March 1, 2017

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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