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Preparation of Gold Nanoparticles-Attached Phosphorescent Nanospheres for Synergistic Photothermal and Photodynamic Therapy

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Gold nanoparticles (GNPs)-attached and Pt(II)-porphyrins (PtTFPP)-encapsulated hybrid nanospheres (GNPs-Pt-NSs) were prepared and used for photothermal and photodynamic combined therapy. These nanospheres were characterized by transmission electron microscopy, dynamic light scattering and absorption spectra. It was found that the nanospheres had spherical size of 120 nm and two absorption bands in 395 and 540 nm assigned to PtTFPP and GNPs, respectively. Owing to the small particle size and positive surface charge, the NSs exhibit efficient cellular uptake. By irradiating with a 540 nm laser, GNPs were capable of producing sufficient hyperthermia for a photothermal effect, while reactive oxygen species could be generated to induce photodynamic cancer cell death under the 405 nm laser irradiation. The anticancer effects of the hybrid nanospheres were examined as photodynamic therapy (PDT), photothermal therapy (PTT), and PTT/PDT combined therapy. Compared with PTT or PDT alone, the combined therapy had a significantly synergistic effect and improved the therapeutic efficacy.
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Keywords: GOLD NANOPARTICLES; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; PT(II)-PORPHYRINS

Document Type: Short Communication

Publication date: March 1, 2017

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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