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Small Angle X-Ray Scattering Characterization of Multifunctional Iron Oxide-Pluronic Nanocarriers: Effect of Temperature and Drug Encapsulation

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Present work aimed to study encapsulation of paclitaxel (PTX) and superparamagnetic iron oxide (SION) into Pluronic F127 (PEO100-PPO65-PEO100) micelles and their effect on micellar structural properties. The nuclear magnetic resonance (NMR) measurements demonstrated that PTX interacted with PPO in the micelle core whereas SION can be found in both blocks. Small angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) results highlighted that the interaction of micelles with PTX did not change the shape of the micelles. The dimensions of core and corona varied as function of drug concentration and led to the larger core upon encapsulation of the drug. The effect of temperature on the structures of Pluronic and Pluronic-PTX were also explored using SAXS. Results showed that the temperature increment from 37 to 50 °C associated with micelles agglomeration and shape transition from sphere to cylinder, which are function of hydrophobicity of the micelles.
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Keywords: MULTIFUNCTIONAL NANOCARRIER; PACLITAXEL; PLURONIC; SAXS; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

Document Type: Short Communication

Publication date: August 1, 2016

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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