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pH Sensitive Polyhedral Fe3O4 Hollow Spheres Towards High Releasing Efficiency of Doxorubicin Hydrochloride

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In order to minimize the side effects and improve the therapeutic efficiency of doxorubicin hydrochloride (DOX), targeted drug delivery and the controlled drug release techniques at the tumor sites are necessary. In this work, polyhedral Fe3O4 hollow spheres were synthesized by using hexamethylenetetramine (HMT) as structure directing agent and modified by using 3-mercaptopropyltrimethoxysilane (MPS). The resulting products (Fe3O4-MPS) possess high magnetism at room temperature, large cavity and high water solubility. Experimental results indicate that the maximal DOX-loading efficiency of Fe3O4-MPS was approximately 88%, and the cumulative releasing efficiency of DOX at pH 5.0 was about 93% over 24 hours. Because of a satisfactory magnetic response and large surface area, DOX-loaded Fe3O4-MPS spheres (Fe3O4-MPS-DOX triads) could quickly reach to the disease tissues and release drug controlled. The lower releasing efficiency of DOX at pH 7.4 (about 8%) could alleviate systemic toxicity of DOX. Hence, Fe3O4-MPS-DOX triads will be a promising drug delivery carrier for targeted cancer therapy.
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Keywords: DOXORUBICIN HYDROCHLORIDE; POLYHEDRAL FE3O4 HOLLOW SPHERES; RELEASING

Document Type: Short Communication

Publication date: August 1, 2016

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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