Fabrication and Anti-Cancer Activity of Natural Ingredient/Extract Loaded Polycaprolactone (PCL) Nanofibres Enhanced by Plasma Treatment
Nanoparticles have attracted considerable interests in healthcare area. Polymer nanofibres play an important role in drug delivery systems due to their distinctive high specific surface area, small pore size and high porosity. We show here fabrication of natural ingredient/extract loaded
polycaprolactone (PCL) nanofibre for anticancer activity. Scanning electron microscopy (SEM) and Fourier transform infrared spectrometer (FT-IR) were employed to investigate the morphology and chemical nature of fabricated nanofibre. Surface hydrophilicity and hydrophobicity of the nanofibres
were evaluated by measuring static contact angles of water. The plasma treatment enhanced the hydrophilicity of the polymer. The cytotoxic efficiency was conducted on HaCaT skin cells. The population of HaCaT cells for control and other natural extract loaded nanofibres were found to be almost
equal.
Keywords: ANTI-CANCER ACTIVITY; CONTACT ANGLE MEASUREMENTS; NANOFIBRE; NATURAL EXTRACT; PCL; PLASMA TREATMENT
Document Type: Short Communication
Publication date: 01 April 2016
- Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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