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Characteristics and In Vivo Osteogenic Effect of Simvastatin-Containing MPEG-PLA Nanoparticles on Bone Regeneration

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Alveolar atrophy has long been a major challenge in clinical dental implant therapy. Simvastatin (SV) is known to enhance osteogenesis, but several limitations, including its inactive lactone and poor absorption, lead to low concentrations of SV at the site of action. Monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA, MP) particles, nanoscale polymeric micelles, possess a unique core–shell architecture and an outstanding nano-bioeffect. So SV-loaded MPEG-PLA nanoparticles (SMPs) were synthesized in this study, We hypothesized that SMP nanoparticles could enhance the in vivo osteogenic effect of SV by evaluating in a critical-sized bone defect in rabbit cranium. The results showed SMPs averaged 41.3 ± 1.6 nm in size. The in vitro cumulative release outcomes showed that the SMPs displayed significant controlled release. The in vivo results revealed that the SMPs obviously enhanced bone formation in the critical-sized bone defect. Thus, SV-loaded MPs could significantly improve the anabolic bone effects of SV in vivo and MP would be a potential carrier system for encapsulating simvastatin.
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Keywords: BONE DEFECT; DRUG DELIVERY SYSTEMS; OSTEOGENESIS; PEG-PLA; SIMVASTATIN

Document Type: Short Communication

Publication date: March 1, 2016

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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