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Fabrication of Acid-Responsive Electrospun Fibers via Doping Sodium Bicarbonate for Quick Releasing Drug

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Acid-responsive electrospun nanofibers are gaining considerable attention as highly versatile tools which offer responsive drug releasing carriers and tissue engineering scaffold. A feasible acidresponsive ibuprofen-loaded electrospun fibers was presented by introducing sodium bicarbonate (NaHCO3) into Poly(lactic-co-glycolic acid) via blend electrospinning. The acid-responsive electrospun fibers showed the uniform micro/nano fiber morphology and porous fibrous structures. In vitro release profiles showed that the ibuprofen release rates of fibers were significantly accelerated after incubation into pH 5.0 compared to pH 7.4 solutions. During the investigational period, almost no mass loss and weight reduction was detected. These acid-responsive electrospun fibers are promising as smart drug carriers for targeted drug delivery and tissue engineering scaffolds.
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Keywords: ACID-RESPONSIVE; BIOMATERIALS; DRUG CARRIERS; ELECTROSPINNING; MICRO/NANO FIBER

Document Type: Short Communication

Publication date: April 1, 2014

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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