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Formulation, Optimization and Characterization of Self Nanoemulsifying Drug Delivery System (SNEDDS) of Paclitaxel for Solubility Enhancement

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In the present study, self-nanoemulsifying drug delivery systems (SNEDDS) of paclitaxel were developed with the objectives of increasing its bioavailability by enhancing its solubility and diminishing P-glycoprotein drug efflux. Ternary phase diagrams were constructed to identify the efficient nanoemulsification regions. Selected formulations from phase diagram were evaluated for various parameters. Droplet size was found to be less than 20 nm with polydispersity index and zeta potential of 0.176 and –38.1 mV respectively.In vitro release study showed upto 99% drug release from SNEDDS in approximately 3 hour. The drug release from SNEDDS was dramatically enhanced compared with that of the suspension (P < 0.05). Thus the present study indicated great potential for enhancing the solubility of paclitaxel which may lead to enhanced bioavailability through oral administration.
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Keywords: BIOAVAILABILITY; MULTIDRUG TRANSPORTER P-GLYCOPROTEIN (PGP); PACLITAXEL; SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM; TERNARY PHASE DIAGRAMS

Document Type: Research Article

Publication date: August 1, 2013

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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