Porous-Silicon Photonic-Crystal Platform for the Rapid Detection of Nano-Sized Superparamagnetic Beads for Biosensing Applications
Biosensing platforms based on functionalized submicron-sized superparamagnetic beads (SPBs) that act as magnetic labels are being extensively researched for applications involving portable, rapid, easy-to-use and highly sensitive point-of-care medical testing (POCT) equipment. Recently,
in order to achieve greater sensitivity and improved quantification, there have been increasing demands for the use of SPBs with diameters of less than 300 nm. However, the detection of low densities of sub-250 nm diameter SPBs using typical magnetoresistive-based biosensors is extremely challenging
due to the intrinsic noise that affects these devices, as well as the weak magnetic signals that are derived from nano-sized SPBs. Here, we demonstrate an easy, quick, and economical method for the detection of small numbers of SPBs by optically monitoring the intensity of light that is reflected
back from porous silicon photonic crystals (multi-layer-PSi) in less than 60 seconds.
Keywords: MULTI-LAYER-POROUS SILICON; NANO SIZED SUPERPARAMAGNETIC BEADS; POINT OF CARE TESTING
Document Type: Short Communication
Publication date: 01 October 2011
- Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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