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Open Access Effect of Ropivacaine nanoparticles on apoptosis of cerebral vascular endothelial cells

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The objective of this study was to investigate the effect of Ropivacaine lactate glycolic acid copolymer nanoparticles on the apoptosis of vascular endothelial cells after cerebral vasospasm (CVS) in rabbits. Thirty New Zealand rabbits were randomly divided into five groups: Sham Operation, control, blank nanoparticles, nanoparticles drug-loaded, and Ropivacaine. A model of subarachnoid hemorrhage (SAH) was established by injecting blood into the rabbits' cisterna magna twice. The mean velocity (VM) and peak systolic velocity (VP) of basilar artery were compared at one, three, and seven days, after which the shape was observed under a light microscope. The diameter of the lumen was measured at seven days after injection. The TUNEL method was used to detect the apoptosis of endothelial cells in the basilar artery. There was no obvious edema or blood clot and the basilar artery was clear in the Sham Operation group. In the control and blank nanoparticles groups, there was obvious swelling of brain tissue, and obvious blood clots were found at the bottom of brain, mostly around the basilar artery and Willis ring. The pool of brain bottom was dark red. Compared with the control and blank nanoparticles group, the swelling of brain tissue in the nanoparticles and Ropivacaine groups was reduced. Administration of Ropivacaine lactate glycolic acid copolymer nanoparticles into the epidural space of the upper thoracic segment in rabbits can reduce the apoptosis of CVS vascular endothelial cells after SAH.
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Keywords: APOPTOSIS; CEREBRAL VASOSPASM; VASCULAR ENDOTHELIAL CELLS

Document Type: Research Article

Publication date: August 1, 2020

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  • Materials Express is a peer-reviewed multidisciplinary journal reporting emerging researches on materials science, engineering, technology and biology. Cutting-edge researches on the synthesis, characterization, properties, and applications of a very wide range of materials are covered for broad readership; from physical sciences to life sciences. In particular, the journal aims to report advanced materials with interesting electronic, magnetic, optical, mechanical and catalytic properties for industrial applications.
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