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Open Access Mechanisms underlying the action of self-assembling short-peptide nano-fiber gel scaffold materials in the aesthetic repair of burn wounds

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To study the mechanism of self-assembling short-peptide nano-fiber gel scaffolds on the aesthetic repair of burns. RADA16-1 assembled short-peptide nano-fiber gel scaffold was prepared using the ultrasonic method. Twenty female SD rats were randomly divided into two groups. Burn model was established using the electrical machinery method. The wound surface of the rats in the experimental group was coated with RADA16-1 and that of the rats in the control group was coated with NaCl. The degree of wound healing, hair follicle growth, hair growth length, and expression of bFGF and EGF were compared between the two groups. RADA16-1 fibers were broken into short fibers under the ultrasonic environment and then reorganized into gels. The degree of wound healing, hair follicle growth, hair growth length, and expression of bFGF and EGF in the experimental group were better than those in the control group. The assembly of short peptide nano-fiber gel scaffolds can effectively repair burn wounds.
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Keywords: Burn Wound; Short Peptide Nanofiber Gel Scaffold; Ultrasound

Document Type: Research Article

Affiliations: Department of Plastic and Burn Surgery, Tianjin First Center Hospital, Tianjin 300192, PR China

Publication date: March 1, 2020

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  • Materials Express is a peer-reviewed multidisciplinary journal reporting emerging researches on materials science, engineering, technology and biology. Cutting-edge researches on the synthesis, characterization, properties, and applications of a very wide range of materials are covered for broad readership; from physical sciences to life sciences. In particular, the journal aims to report advanced materials with interesting electronic, magnetic, optical, mechanical and catalytic properties for industrial applications.
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