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Open Access Development of cationic polymer-based nanoplatform for insulin delivery and diabetes treatment

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Due to the high molecular weight, hydrophilicity, and pH/enzyme sensitivity of proteins, effectively delivery of therapeutic proteins remains many difficulties. In this study, a novel nanoplatform for insulin delivery was established, in which a kind of tunable cationic polymer based on arginine was chosen as the nanocarrier. The nanocomplexes were formed with the cationic polymers and insulin under the electrostatic reactions. Then the relationship between the chemical structure of polymers and physicochemical properties of nanocomplex was systematically investigated among the particle size, surface charge, cytotoxicity, cellular internalization ability and finally therapeutic effects. It was confirmed that the structure of polymers affected their hydrophobicity, subsequently influencing the physicochemical properties of nanocomplex and further the therapeutic effects of nanocomplex. The in vivo results also proved that the suitable polymer with an optimal weight ratio of materials and proteins could obtain a promising therapeutic effect on Type 1 diabetes.
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Keywords: Cationic Polymers; Insulin Delivery; Nanocomplex; Type 1 Diabetes

Document Type: Research Article

Affiliations: 1: Institute of Translational Medicine, Shenzhen University Health Science Center, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, 518035, China 2: Shenzhen Lansi Institute of Artificial Intelligence in Medicine, Shenzhen, Guangdong, 518035, China

Publication date: March 1, 2020

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  • Materials Express is a peer-reviewed multidisciplinary journal reporting emerging researches on materials science, engineering, technology and biology. Cutting-edge researches on the synthesis, characterization, properties, and applications of a very wide range of materials are covered for broad readership; from physical sciences to life sciences. In particular, the journal aims to report advanced materials with interesting electronic, magnetic, optical, mechanical and catalytic properties for industrial applications.
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