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Open Access Evaluation of a recombinant bacillus calmette-guérin vaccine expressing P39-L7/L12 of Brucella melitensis: An immunization strategy against brucellosis in BALB/c mice

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Brucellosis is a chronic infectious disease caused by bacteria from the genus Brucella. It has a serious global economic impact, and poses a threat to public health. Ideally, vaccines should exhibit a safe profile as well as enhanced protective efficacy. However, there are no licensed vaccines available for humans against brucellosis. In this study, for the first time, a recombinant BCG (rBCG) vaccine expressing the P39-L7/12 fusion protein of Brucella melitensis against brucellosis was constructed. The rBCG vaccine elicited strong antigen-specific humoral and T cell-mediated immunity in vivo. The rBCG vaccine also induced a significant level of protection following challenge with a virulent strain of B. melitensis M28 in BALB/c mice. Furthermore, the protection level induced by the rBCG vaccine was significantly higher than that induced by BCG. Collectively, these results suggested that rBCG vaccine acted as a suitable vaccine candidate and a new strategy against human brucellosis.
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Keywords: Brucellosis; P39-L7/12; Recombinant BCG; Vaccine

Document Type: Research Article

Affiliations: 1: Beijing University of Chinese Medicine, Beijing 100029, PR China 2: Inner Mongolia Key Lab of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010058, Inner Mongolia, PR China 3: School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010058, Inner Mongolia, PR China

Publication date: March 1, 2020

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