Fabrication of CdS bound pyrazole carboxamide conjugated nanoassemblies and their applications
In this work, a new family of nanoassemblies were developed by conjugating the pyrazole-based moiety 4-Amino-1-methyl-3-n-propyl-5-pyrazolecarboxamide (AMP) with the chelating agent1,3-diamino-2hydroxypropane-N,N,N,N-tetraacetic acid (TTA). By altering the ratio of AMP added, three conjugates were synthesized. Each of those conjugates were self-assembled at varying pH values to promote the growth of higher order supramolecular structures. The results showed that growth was pH dependent as well as dependent on the ratio of AMP to TTA utilized to form the conjugates. While under acidic conditions, primarily nanofibers were observed, under basic conditions, nanovesicles were formed. Due to the chelating ability of the conjugates, CdS nanoparticles were then grown on the assemblies. The hybrid CdS nanoparticle-bound assemblies showed distinct anti-fungal activity as well as cytotoxicty toward HeLa cells. Thus we have developed a new family of supramolecular assemblies with potential applications in biosensors or in environmental monitoring.
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Document Type: Research Article
Publication date: December 1, 2014
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