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Open Access Fabrication of CdS bound pyrazole carboxamide conjugated nanoassemblies and their applications

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In this work, a new family of nanoassemblies were developed by conjugating the pyrazole-based moiety 4-Amino-1-methyl-3-n-propyl-5-pyrazolecarboxamide (AMP) with the chelating agent1,3-diamino-2hydroxypropane-N,N,N,N-tetraacetic acid (TTA). By altering the ratio of AMP added, three conjugates were synthesized. Each of those conjugates were self-assembled at varying pH values to promote the growth of higher order supramolecular structures. The results showed that growth was pH dependent as well as dependent on the ratio of AMP to TTA utilized to form the conjugates. While under acidic conditions, primarily nanofibers were observed, under basic conditions, nanovesicles were formed. Due to the chelating ability of the conjugates, CdS nanoparticles were then grown on the assemblies. The hybrid CdS nanoparticle-bound assemblies showed distinct anti-fungal activity as well as cytotoxicty toward HeLa cells. Thus we have developed a new family of supramolecular assemblies with potential applications in biosensors or in environmental monitoring.

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Keywords: ANTIFUNGAL; NANOASSEMBLIES; PYRAZOLE; SELF-ASSEMBLY

Document Type: Research Article

Publication date: December 1, 2014

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  • Materials Express is a peer-reviewed multidisciplinary journal reporting emerging researches on materials science, engineering, technology and biology. Cutting-edge researches on the synthesis, characterization, properties, and applications of a very wide range of materials are covered for broad readership; from physical sciences to life sciences. In particular, the journal aims to report advanced materials with interesting electronic, magnetic, optical, mechanical and catalytic properties for industrial applications.
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