Multifunctional Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles for Targeted Optical Imaging,T 1 Magnetic Resonance Imaging and Photodynamic Therapy
We report the development of multi-functional uniform nanoparticles comprising a hollow manganese oxide core and a functionalized mesoporous silica shell (H–[email protected]2 (Ir)@–FA, Ir: an emissive iridium complex, FA: folic acid) for use as theranostic nanocomposites that combine four-in-one functionality, i.e., dual imaging (both magnetic resonance and optical), specific targeting and therapy in a single unit. The H–[email protected]2 (Ir)–FA nanoparticles (NPs) demonstrate its versatility in various applications. (1) The magnetic core provides the capability for T 1magnetic resonance imaging. (2) Phosphorescent iridium complex serves as both photosensitizer and the luminescent chromophore. (3) The nano-channels in the mesoporous silica shell increase the free diffusion of oxygen and water permeability, enhancing photodynamic therapy (PDT) and T 1 signal, respectively. (4) Folic acid anchored on the outermost surface is able to target at specific cells for bimodal imaging and PDT. Proof of concept is provided in the in-vitro cell testing of H–[email protected]2 (Ir)–FA NPs, which demonstrates excellent targeting specificity, minimal collateral damage and highly potent therapeutic effect.
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Document Type: Research Article
Publication date: June 1, 2011
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