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Comprehensive Molecular Analysis of the Responses Induced by Titanium Dioxide Nanoparticles in Human Keratinocyte Cells

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Engineered nanoparticles (ENPs) such as TiO2 are widely used in products such as cosmetics, clothing, food packaging, drug delivery systems, biosensors, surface cleaning agents, catalysis, etc. due to their unique physico-chemical properties. Extensive application has also increased their opportunities for exposure of these ENPs to human. The safe production and use of ENPs requires improvement in our understanding towards their possible impact on human. The present study demonstrates that exposure of TiO2 ENPs (8 μg/mL) to human keratinocyte cells (HaCaT) induces the expression of different genes involved in DNA damage, response against stress, cell cycle, transportation and secretion, immune response and apoptosis. These alterations in the expression profile may lead to the mutagenicity; carcinogenicity and cytotoxicity of the exposed cells. The data of the present study can also be helpful in exploring the other pathways induced by the exposure of TiO2 ENPs in HaCaT cells.
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Keywords: CELL CYCLE; DNA DAMAGE; HUMAN KERATINOCYTE CELLS; OXIDATIVE STRESS; TIO2 ENPS; TRANSPORTATION AND SECRETION

Document Type: Research Article

Publication date: March 1, 2014

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  • Journal of Translational Toxicology is an international peer-reviewed journal, publishes original research articles, short communications, case reports and reviews dealing with all aspects of toxicology including in vitro, in vivo and mechanistic toxicology, human biomonitoring and environmental risk assessment, biochemical and molecular effects of drugs/toxicants, development of biomarkers for monitoring the drug/toxicant induced injury, in silico approaches for predictive toxicity testing, innovative methods and approaches in risk assessment, sensors, devices and chips for detection of biomolecules, toxicants and contaminants, nanomedicine, nanotoxicology, and much more.
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