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Safranal Analogs as Antiproliferative Agents Against Pancreatic Cancer

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Safranal is one of the bioactive constituents present in Crocus Sativus which is known to display a broad range of pharmacological activities and is especially well-known for its neuropsychological effects. Despite its promising properties as a therapeutic agent, its potential as an anti-inflammatory and anti-neoplastic agent has not been fully explored and its mechanism of anticancer action remains unknown. In the present work we have investigated the antiproliferative activities of Safranal and a designed series of its analogs as potential COX-2 inhibitors with a view to understand which chemical modification potentiates its antiproliferative activity. Molecular Docking studies were carried out to identify the key residues interacting with these derivatives in the COX-2 cavity. All compounds were tested against two pancreatic cancer cell lines while western blot studies were carried out to confirm inhibition of COX-2 and other transcription factors in the inflammatory pathway.
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Keywords: ANTI-CANCER; CYCLOOXYGENASE-2; IL8; INOS; PANCREATIC CANCER; PHYTOCHEMICALS; SAFRANAL

Document Type: Research Article

Publication date: 01 March 2017

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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