Safranal Analogs as Antiproliferative Agents Against Pancreatic Cancer
Safranal is one of the bioactive constituents present in Crocus Sativus which is known to display a broad range of pharmacological activities and is especially well-known for its neuropsychological effects. Despite its promising properties as a therapeutic agent, its potential as an anti-inflammatory and anti-neoplastic agent has not been fully explored and its mechanism of anticancer action remains unknown. In the present work we have investigated the antiproliferative activities of Safranal and a designed series of its analogs as potential COX-2 inhibitors with a view to understand which chemical modification potentiates its antiproliferative activity. Molecular Docking studies were carried out to identify the key residues interacting with these derivatives in the COX-2 cavity. All compounds were tested against two pancreatic cancer cell lines while western blot studies were carried out to confirm inhibition of COX-2 and other transcription factors in the inflammatory pathway.
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Document Type: Research Article
Publication date: March 1, 2017
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