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Anxiolytic Effects of Trachyspermum ammi Seeds in Mice

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Ajowan (Trachyspermum ammi) is a popular kitchen spice which is routinely used as home remedy for the management of a wide range of gastro-intestinal disorders. Despite a number of studies on Ajowan, there is lack of sufficient data to support the traditional claims of anti-anxiety property of Ajowan. Therefore, the present study was designed to evaluate the effect of T. ammi seeds powder (TASP) on the anxiety like behavior in mice. TASP was administered along with diet in concentration of 0.5%, 1.0% and 2.0% w/w for ten consecutive days. Anxiolytic behavior was studied using elevated plus mazes (EPM), hole board test (HBT) and light and dark paradigm (LDP). Ten days successive administration of TASP along with diet led to rise in open arm entries (number and time spent) in EPM, increase in nose pocking behavior in HBT and more time spent in light compartment in LDP. These results suggest the anxiolytic potential of Ajowan seeds and may prove to be an effective and possibly safe therapeutic option to treat anxiety.
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Keywords: AJOWAN; ALPRAZOLAM; ANXIETY; ANXIOLYTIC; ELEVATED PLUS MAZE; HOLE BOARD TEST; TRACHYSPERMUM AMMI

Document Type: Research Article

Publication date: March 1, 2017

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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