Possible Role of Serotonin and Selective Serotonin Reuptake Inhibitors in Suicidal Ideations and Attempts
Suicide is the leading cause of death and almost one million people die from suicide every year. Depression is the main predictor of suicidal ideation and attempts. It has been reported that about 85% of patients with major depression have suicidal ideation, 32% make a suicide attempt, and 2.5% to 7% commits suicide. SSRIs are currently the most frequently prescribed therapeutic agents in the treatment of depression. SSRIs offer various advantages over other categories of drugs used in the treatment of depression. However SSRIs therapy increases the risk of suicides in the suffering patients. The present manuscript suggest the link between suicidality and depression and the mechanism by which SSRIs that are used in the treatment of depression potentiates the further risk of suicidal ideations and attempts in these patients.
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Document Type: Research Article
Publication date: March 1, 2017
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