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Possible Role of Serotonin and Selective Serotonin Reuptake Inhibitors in Suicidal Ideations and Attempts

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Suicide is the leading cause of death and almost one million people die from suicide every year. Depression is the main predictor of suicidal ideation and attempts. It has been reported that about 85% of patients with major depression have suicidal ideation, 32% make a suicide attempt, and 2.5% to 7% commits suicide. SSRIs are currently the most frequently prescribed therapeutic agents in the treatment of depression. SSRIs offer various advantages over other categories of drugs used in the treatment of depression. However SSRIs therapy increases the risk of suicides in the suffering patients. The present manuscript suggest the link between suicidality and depression and the mechanism by which SSRIs that are used in the treatment of depression potentiates the further risk of suicidal ideations and attempts in these patients.
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Keywords: ANTIDEPRESSANTS; DEPRESSION; SEROTONIN; SUICIDE

Document Type: Research Article

Publication date: March 1, 2017

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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