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GC-MS and IR Studies on the Six Possible Ring Regioisomeric Dimethylphenylpiperazines

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The complete series of regioisomeric dimethylphenylpiperazines were synthesized and evaluated using GC-MS and FT-IR. The EI mass spectra show fragment ions characteristic of both the dimethylphenyl and the piperazine portions of the molecules. These fragments include the dimethylphenyl aziridinium cation at m/z 148 and dimethylphenyl cation at m/z 105. In addition, the low mass ion at m/z 56 for the C3H6N+ was observed in all piperazine EI spectra. Perfluoroacylation of the secondary amine nitrogen for each of the six regioisomers yielded amides whose mass spectra showed some differences in relative abundance of fragment ions without the appearance of any unique fragments. FTIR provides direct confirmation for differentiation of the six regioisomeric aromatic ring substituted dimethylphenylpiperazines. GC separation of this series of compounds was accomplished on an Rtx-200 column and retention appears related to the degree of steric crowding of the aromatic ring substituents.
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Document Type: Research Article

Publication date: March 1, 2017

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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