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Hepatoprotective Activity of Alkaloid Fractions from Ethanol Extract of Murraya koenigii Leaves in Experimental Animals

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Liver diseases, such as jaundice, cirrhosis and fatty liver, are very common worldwide. Hepatotoxicity refers to liver dysfunction associated with an overload of drugs or xenobiotics. Murraya koenigii (family: Rutaceae) is a highly valued plant for its characteristic aroma and medicinal value. This plant is a rich source of carbazole alkaloids having antioxidant activity. The study was designed to evaluate the protective effect of alkaloid fractions from the ethanolic extract of M. koenigii leaves (AMK) in acute experimental liver injury induced by carbon tetrachloride and paracetamol. Animals were divided into five groups of five. Carbon tetrachloride and paracetamol were used as liver injury inducing agents. Group 1 received only the vehicle, Group 2 was treated with carbon tetrachloride (1 ml/kg, p.o.) or paracetamol (1 gm/kg, p.o.) on ninth day and Group 3 was treated with silymarin (100 mg/kg/day, p.o.) for 9 days respectively and then exposed to both the inducing agent on ninth day. The animals were sacrificed on 9th day and subjected to evaluation of biomarker enzymes, in vivo antioxidant activity, and histopathological changes. In the Group 4 and 5, AMK (30 and 100 mg/kg, p.o.) significantly reduced the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) suggesting a hepatoprotective effect and also prevented the increases in liver weight compared to hepatotoxin treated controls. AMK significantly increased the levels of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), while levels of lipid peroxidation (LPO) were significantly reduced. Histological examination of liver tissue supported the idea that AMK was acting via hepatoprotective mechanism. From current study, it may be concluded that the alkaloid fraction isolated from ethanolic extract of M. koenigii leaves has potential hepatoprotective activity.
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Keywords: ALKALOID; ANTIOXIDANT; CARBON TETRACHLORIDE; ETHANOLIC EXTRACT; HEPATOPROTECTIVE ACTIVITY; HEPATOTOXICITY; MURRAYA KOENIGII; PARACETAMOL

Document Type: Research Article

Publication date: March 1, 2017

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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