In Vivo and Computational Chemo-Inhibition of Peritoneal Tumor Angiogenesis Studies of a New Pyrazolyl Alcohol Derivative
The antiangiogenic effects of compound 4-(quinolin-3-yl)-1-[6-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-ol (P) was studied in Swiss albino mice induced with Ehrlich ascites tumor (EAT) cells. Compound P (100 μg/ml body weight) was injected intraperitoneally into EAT bearing mice for alternative days and sacrificed on 13th day. Later ascites fluid volume and cell number was estimated in experimental animals. During the experimental period body weight of the animals was monitored. Inner lining of mice peritoneal cavity was examined to determine the antiangiogenesis property. DNA fragmentation study was also carried. Molecular docking studies were carried out by standard methods against VEGF target. In this study, 4-(quinolin-3-yl)-1-[6-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-ol (P) exhibited antiangiogenic effect against tested animals.
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Document Type: Research Article
Publication date: March 1, 2017
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