The Effect of Silica Coatings on the Structural, Magnetic and Antimicrobial Properties of Silver Doped Manganite Magnetic Nanoparticles for Biomedical Applications
Surface modification of magnetic nanoparticles with biocompatible materials is usually required for biomedical applications. La0.80Ag0.15MnO3 (LAMO) magnetic nanoparticles (MNPs) were synthesized by the sol–gel auto combustion synthesis with the nanoparticles subsequently coated with silica. The effect of the coatings on the structural, morphology, magnetic properties, colloidal stability and antimicrobial properties of LAMO nanoparticles were studied using powder X-ray diffraction, thermogravimetric analysis, field emission scanning electron microscopy, zeta potential and vibrating sample magnetometer. The crystalline perovskite structure of LAMO was retained after silica coating but with a reduction in crystallinity. Also, there was a reduction of agglomeration and average crystallite size (48 nm) were the same after silica coating. The zeta potential of the coated sample revealed a considerable high colloidal stability value (–27.70 mV) at physiological pH 7.4. The magnetization values of 26 emu/g and 25 emu/g recorded for bare and coated LAMO samples, respectively show that LAMO MNPs retained its ferromagnetic behaviour after silica coating. Bare and silica coated LAMO gave very high bactericidal effect against S. aureus however, there was no change in the antimicrobial properties of LAMO MNPs with silica coating. These results show that while the silica coating influences greatly the morphology and colloidal stability of LAMO nanoparticles, it had virtually no effect on the crystalline structure and size, magnetization and the antimicrobial properties.
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Document Type: Research Article
Publication date: December 1, 2017
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- Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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