Preparation of Chitosan-Sodium Sodium Tripolyphosphate Nanoparticles via Reverse Microemulsion-Ionic Gelation Method
In this study, chitosan (CS)-sodium sodium tripolyphosphate (STPP) (CS-STPP) nanoparticles were fabricated via reverse microemulsion-ionic gelation method. A series of experiments were conducted to optimize the constitution of reverse microemulsion system and the obtained CS-STPP nanoparticles
were then characterized by Fourier transform infrared spectrum (FT-IR) and scanning electron microscope (SEM). The concentration of Tween-80 and Span-80 were 6% and 2% respectively when the ratio of water phase to oil phase was 1/7. A narrow size distribution and good dispersion of the obtained
CS-STPP nanoparticles were obtained when the stirring speed was 400 rpm/min, with diameter being 552±14 nm. The FT-IR results for the CS-STPP nanoparticles also indicated that the CS was cross-linked with the STPP. These results are very important for the CS-STPP nanoparticles when
used as drug carriers.
Keywords: CHITOSAN; REVERSE MICROEMULSION-IONIC GELATION METHOD; SODIUM TRIPOLYPHOSPHATE
Document Type: Research Article
Publication date: 01 August 2015
- Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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