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Cancer-Testis Antibodies Mediated Superparamagnetic Nanoprobes as Tumor Targeting Contrast Agents for In Vitro Magnetic Resonance Imaging

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The key to molecular imaging is discovery of disease biomarkers and development of highly sensitive and specific probes with strong signal intensity. Sperm protein 17 (Sp17), a novel cancer-testis antigen, can be a candidate target for cancer immunotherapy and molecular diagnosis. In this study, nanoprobes were prepared by linking anti-human Sp17 antibodies (anti-Sp17) on the surface of chitosan (CS) coated suparamagnetic nanoparticles. Results showed that the anti-Sp17 probes were well-grafted to suparamagnetic nanoparticles while keeping high bioactivity. Magnetic resonance (MR) signal intensity of cells was measured in agarose phantoms after labeling the human Sp17 gene transfected ovarian cancer HO-8910 cells with the nanoprobes. The nanoprobes were used to target cells and no obvious non-specific adsorption occurred. Cytotoxicity test demonstrated that the nanoprobes have limited cell toxicity. The prepared nanoprobes can thus potentially be used as MR contrast agents for early tumor diagnosis and immunotherapy.
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Keywords: ANTI-HUMAN SP17 ANTIBODIES; IN VITRO; MAGNETIC NANOPARTICLES; RESONANCE IMAGING; TARGETING MAGNETIC

Document Type: Research Article

Publication date: October 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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