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The Effects of Hypoxia on Uptake of Positively Charged Nanoparticles by Tumor Cells

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Negatively and positively charged iron oxide nanoparticles and gold nanoparticles were prepared and characterized by transmission electronic microscopy and dynamic light scattering. The effects of oxygen microenvironment on nanoparticle uptake by tumor cells were investigated. It was found that the uptake of negatively and positively charged nanoparticles increased under hypoxic condition compared with normoxic condition; however, the increased extent of positively charged nanoparticles was far higher than that of the negatively charged ones. Similar phenomena were observed in both of iron oxide nanoparticles and gold nanoparticles. It is well-known that solid tumor is universally hypoxic, positively charged nanoparticles are thus a potential system for hypoxia-targeted theragnostics of hypoxic tumors.
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Document Type: Research Article

Publication date: October 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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