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Antimicrobial Activities of Basic Magnesium Hypochlorite Nanoparticles on Escherichia Coli and Staphylococcus Aureus

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The basic magnesium hypochlorite (BMH) nanoparticles were prepared by two micro-emulsion techniques. The antimicrobial activities of BMH nanoparticles on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were investigated. The BMH nanoparticles were characterized by scanning electron microscope (SEM) and Malvern Instruments. The thermostability of BMH nanoparticles was measured by TG-DSC. The antibacterial activities of BMH nanoparticles were investigated by broth dilution test, the concussion flask method, the antibacterial circle test, and the antibacterial mechanism was discussed by scanning electron microscope (SEM). The results showed that the average size of the BMH nanoparticles was 278 nm. The BMH nanoparticles had excellent thermostability comparing with other antibacterial agents, the antibacterial circle diameters were increased with the increase in the content of BMH nanoparticles mixing with CaCO3, and the minimum bactericidal concentration (MBC) of BMH nanoparticles on E. coli andS. aureus were 1250 g/mL, the antibacterial rate of the BMH nanoparticles againstE. coli reached 99.2% for 6 h at the MBC of BMH nanoparticles and reached 99% for 3 h against S. aureus. The excellent antimicrobial activity of BMH nanoparticles might be caused by synergistic effect of releasing reactive oxygen species (ROS) and absorption.
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Document Type: Research Article

Publication date: October 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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