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Design and Evaluation of Electrospun Nanofibers for the Enhancement of Dissolution Rate of Meloxicam

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Up to 40 percent of new chemical entities discovered by the pharmaceutical industry today are poorly soluble and lipophilic compounds. The poor solubility and wettability of meloxicam leads to poor dissolution and hence the drug shows poor bioavailability. The present study is aimed at increasing the dissolution rate of the drug using the electrospinning technique. The nanofibers were prepared using the different drug:polymer ratios. The optimized formulation was characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and the in-vitro dissolution rate studies. The meloxicam nanofibers prepared by electrospinning technique demonstrated higher drug release rate in comparison to the pure meloxicam. Moreover, in this technique the process parameters: feed rate, voltage, distance, were also optimised to obtain the maximum nanofiber yield and the satisfactory particle size.
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Keywords: DISSOLUTION RATE; ELECTROSPINNING; MELOXICAM

Document Type: Research Article

Publication date: October 1, 2013

More about this publication?
  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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