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Identifying Intronic miRNA and mRNA Regulatory Network in Renal Cell Carcinoma by Paired Expression Data

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Expressions of some miRNAs are abnormal in cancer, so it is significance to study the regulatory network of miRNA in cancer. Intronic miRNA is a new class of miRNA which is derived from introns. The expression of intronic miRNA and its host mRNA are positively related based on the co-transcriptional event. At the same time, miRNA inhibits its target mRNAs, so the expressions of them are negatively related. According to the above two quantitative relations, we can identify the regulatory network among host mRNAs, intronic miRNAs and target mRNAs by analyzing paired microarray data of miRNA and mRNA. In this article, we analyze the abnormal co-expression relationships between intronic miRNAs and their host mRNAs, and abnormal inhibitive effects between intronic miRNAs and their target mRNAs by using paired miRNA and mRNA expression data which are obtained from tissues of renal cell arcinoma and their adjacent normal tissues. Finally we obtained 18 abnormal relationships between host mRNAs and intronic miRNAs, and 29 abnormal relationships between intronic miRNAs and target mRNAs in renal cell arcinoma.
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Keywords: HOST MRNA; INTRONIC MIRNA; RENAL CELL ARCINOMA; TARGET MRNA

Document Type: Research Article

Publication date: October 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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