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Preparation, Characterization and Toxicity Evaluation of Monodisperse Oxytetracycline-Loaded Poly(hydoxyethylmethacrylate) Nanoparticles for Oral Therapy

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Infectious diseases such as anaplasmosis continue to cause serious health problems in domestic animals around the world. Due to climatic variations such as global warming and continued drug resistance in infectious organisms, prevention and control of virulent diseases have become a challenging task of national and global significance. The anaplasmosis organism is susceptible to antibiotics include oxytetracycline. Unfortunately, cattle showing clinical signs usually respond to high dosages of oxytetracycline given by injection. Since biodegradable polymers have been extensively studied for numerous drug delivery systems, nanoparticles could be used as oxytetracycline antibiotics carriers for oral delivery. In the present study, we describe the preparation, characterization and toxicity assay of oxytetracycline-loaded polyhydroxyethylmethacrylate nanoparticles (OTCpHEMA-NPs). The nanoparticles prepared by emulsion method were evaluated for their particle size, encapsulation efficiency and acute toxicity assays in vivo. Different characterization methods, notably Dynamic light scattering, Scanning electron microscopy, Atomic force microscopy and Infrared spectroscopy were appropriately utilised to confirm the drug content and in vitro release. Hemolytic and in vivo toxicity studies were found to be acceptable for oral drug therapy at the nanoscale level in order to reduce the possible threat by free radical generation in vivo.
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Keywords: BIOCHEMICAL PARAMETERS; HEMOLYSIS; HISTOPATHOLOGY; OXYTETRACYCLIN; PHEMA NANOPARTICLES; TOXICITY

Document Type: Research Article

Publication date: August 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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